Design and fabrication of porous chitosan scaffolds with tunable structures and mechanical properties.
Xu Y., Xia D., Han J., Yuan S., Lin H., Zhao C.
Laboratory Study, published in Carbohydr Polym (2017) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Carbohydr Polym (2017)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 28962760
- DOI
- 10.1016/j.carbpol.2017.08.069
- Citations
- 36
Abstract (original English)
Chitosan-based porous scaffolds are of great interest in biomedical applications because of their biodegradability and biocompatibility. However, the poor mechanical properties of these scaffolds hinder their broad utility. In the present study, a novel compression method was developed to fabricate chitosan scaffolds with high mechanical strength and tuneable topography, based on the ionic strength and pH-dependent solubility of chitosan. When the compressive ratio increases from 1 to 8, the compressive elastic modulus of the scaffold increases from 5.2kPa to 520kPa and the porosity decreases from 94.1% to 82.5%. Furthermore, the number of human adipose-derived stem cells adhering to the scaffolds increases as the compressive ratio increases, owing to the high density of the chitosan fibres. This method does not require external cross-linker agent, sophisticated instrumentation and/or technical proficiency and could be extended to other polysaccharides.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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