Development of Graphene Oxide-/Galactitol Polyester-Based Biodegradable Composites for Biomedical Applications
Natarajan J., Madras G., Chatterjee K.
Laboratory Study, published in ACS Omega (2017) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- ACS Omega (2017)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 30023749
- PMCID
- PMC6044677
- DOI
- 10.1021/acsomega.7b01139
- Citations
- 15
Abstract (original English)
We have developed nanocomposites based on galactitol/adipic acid in the molar ratio of 1:1 with different weight percentages of graphene oxide (GO). The objective of this study was to analyze the effect of enhanced physicochemical properties achieved due to the addition of GO to the polymers on cellular responses. The chemical structures of the polymer and composites were confirmed by Fourier transform infrared spectroscopy. Scanning electron microscopy revealed the uniform distribution of GO in the polymers. Differential scanning calorimetry showed no significant variation in the glass-transition temperature of the nanocomposites. Dynamic mechanical analysis demonstrated the increase of Young's modulus with the increase in the addition of GO to the polymer from 0.5 to 1 wt % and a dramatic decrease in modulus with the addition of 2 wt % GO to the polyester. Contact angle analysis illustrated a slight increase in hydrophilicity with the addition of GO to the polyester. Investigations on the hydrolytic degradation and dye release were performed and revealed that the degradation and release decreased with the increase in the weight percentages of GO but increased for 2 wt % GO with the polymer. The rates of degradation and dye release followed first-order and Higuchi kinetics, respectively. The initial in vitro cytocompatibility studies exhibited minimal toxicity. Mineralization
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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