[The development of the interfollicular epidermis in rats following autotransplantation].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Under study were changes to the structure of the rat epidermis detached with the help of incomplete vacuum after its autotransplantation onto the surface of the subcutaneous fat. The epidermis was transferred from the donor area onto the receptive bed protected by a preserving chamber with the help of the glue partly soluble backing. The transplanted epidermis, despite certain traumatization during the detachment, preserves its vital capacity and is actively developing under new conditions during the whole period of the investigation (28 days). Necrotic areas are eliminated within 3 days. As long as up to the 10th day the transplanted epidermis becomes considerably thicker due to the increased amount of layers of nucleus-containing cells. On the 5-14th days there occur single ingrowths of the epidermis into the thickness of the formed granulation tissue. During the following weeks stabilization of the transplant structures takes place. However, even on the 28th day the transplanted epidermis has no morphological distinctions from the intact epidermis.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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