Development of silica grafted poly(1,8-octanediol-co-citrates) hybrid elastomers with highly tunable mechanical properties and biocompatibility.
Du Y., Ge J., Shao Y., Ma PX., Chen X., Lei B.
Laboratory Study, published in J Mater Chem B (2015) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Mater Chem B (2015)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 32262499
- DOI
- 10.1039/c4tb02089h
- Citations
- 12
Abstract (original English)
Biodegradable elastomers are attractive in soft tissue regeneration due to their biomimetic viscoelastic properties and biocompatibility. However, conventional elastomers are inherently weak and lack the bioactivity required for highly efficient tissue regeneration. Silica-based biomaterials have shown high mechanical stiffness and special bioactivities including stimulating osteogenesis and angiogenesis by enhancing corresponding gene expressions. Here, by a facile polymerization, we synthesized a series of silica grafted poly (1,8-octanediol-co-citrate) (SPOC) hybrid elastomers with highly tunable physicochemical properties and bioactivities. The silica phase was successfully grafted to the side chain of POC. The silica phase incorporation significantly endowed POC elastomers with highly controlled thermal stability, mechanical properties, hydrophilicity, biodegradation and biocompatibility. The tensile strength, initial modulus and elongation of SPOC hybrid elastomers were highly tunable and range from 2-15 MPa, 4-25 MPa and 50-140% respectively, which is almost a four-fold enhancement compared with pure POC elastomers. In addition, SPOC elastomers significantly enhanced the proliferation and metabolic activities of multiple cell lines including the adipose-derived stem cells, fibroblasts, myoblasts and osteoblasts, indicating their high biocompatibility. These optimized str
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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