Developments of Thermosensitive Hydrogel for Maxillofacial Bone Regeneration

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Maxillofacial bone defects usually lead to facial deformities and multifunctional impairments, which tremendously damage patients' mental health and social functioning. Recently, the thermosensitive hydrogel combined with seed cells and growth factors has offered a novel approach for maxillofacial bone regeneration. Remarkably responsive to external temperature changes, thermosensitive hydrogel can transform between sol and gel states. Furthermore, its unique properties, such as fluidity, minimally invasive injectability, localized applicability, and controllable drug release, have been increasingly recognized, endowing it with significant promise in bone regeneration. Cutting-edge research on the effects of thermosensitive hydrogels has been reviewed. However, the mechanisms involved in promoting bone regeneration in the maxillofacial region have not yet been established. This article represents the first review of the specific mechanism of thermosensitive hydrogel in angiogenesis and neurogenesis, specifically focusing on its role in maxillofacial osteogenesis. Finally, the article examines the scaffold and drug delivery capabilities of thermosensitive hydrogel in maxillofacial osteogenesis. This review is expected to provide some insights into the advanced developments of thermosensitive hydrogel for maxillofacial bone regeneration.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.