SVF
Level D· Scientific groundwork from lab and animal studiesAnimal StudyPubMed

Differential Effect of Two Transplantation Methods of Adipose-derived Mesenchymal Stem Cells on Hearing Improvement in Simulated Aging Rats.

Liu J., Wang X., Li N., Chen D., Yang D.

Animal Study on Systemic / IV, published in Transplant Proc (2025) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
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This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Animal Study
Journal
Transplant Proc (2025)
Country
United States
Reported sample size
—
Source database
PubMed
PMID
41193324
DOI
10.1016/j.transproceed.2025.10.003

Abstract (original English)

Background Presbycusis is an age-related condition characterized by symmetrical bilateral hearing loss that progresses to total deafness in severe cases. Mesenchymal stem cells demonstrate strong therapeutic and regenerative potential, making it worthwhile to explore optimal transplantation pathways for improving age-related hearing loss. Methods Rats were injected with D-galactose to establish an animal model simulating aging. Adipose-derived stem cells were injected intravenously and into the auditory cortex. The hearing of rats was assessed indirectly through the establishment of an acoustic fear conditioned reflex and directly evaluated by the auditory brainstem response. Gabaergic neurons in the auditory cortex were detected using indirect immunofluorescence, and apoptosis was detected using the terminal uridine nick-end labeling method. Results In comparison with the control group, rats in the model B group exhibited a poor association between sound and electrical stimulation. Similar results were observed in the group injected intravenously with adipose-derived stem cells (group C). However, acoustical fear conditioning was more effectively established in the auditory cortex injection group (group D). Auditory brainstem response analysis revealed a significantly lower hearing threshold in group D compared with group B, indicating a more pronounced hearing recovery in rat

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
AnimalsMesenchymal Stem Cell TransplantationEvoked Potentials, Auditory, Brain StemRatsApoptosisAgingHearingMaleDisease Models, AnimalPresbycusis
Systemic / IV
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