Differential Gene Expression in Longissimus Dorsi Muscle of Hanwoo Steers-New Insight in Genes Involved in Marbling Development at Younger Ages
de Las Heras-Saldana S., Chung KY., Kim H., Lim D., Gondro C., van der Werf JHJ.
Animal Study, published in Genes (Basel) (2020) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Genes (Basel) (2020)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 33233382
- PMCID
- PMC7700136
- DOI
- 10.3390/genes11111381
- Citations
- 13
Abstract (original English)
The Korean Hanwoo breed possesses a high capacity to accumulate intramuscular fat, which is measured as a marbling score in the beef industry. Unfortunately, the development of marbling is not completely understood and the identification of differentially expressed genes at an early age is required to better understand this trait. In this study, we took muscle samples from 12 Hanwoo steers at the age of 18 and 30 months. From the contrast between age and marbling score, we identified in total 1883 differentially expressed genes (FDR SLC38A4 , ABCA10 , APOL6 , and two novel genes (ENSBTAG00000015330 and ENSBTAG00000046041) were up-regulated in the high marbling group. From the protein-protein interaction network analysis, we identified unique networks when comparing marbling scores between different ages. Nineteen genes ( AGT , SERPINE1 , ADORA1 , FOS , LEP , FOXO1 , FOXO3 , ADIPOQ , ITGA1 , SDC1 , SDC4 , ITGB3 , ITGB4 , CXCL10 , ACTG2 , MX1 , EDN1 , ACTA2 , and ESPL1 ) were identified to have an important role in marbling development. Further analyses are needed to better understand the role of these genes.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.