Differential lipid metabolism in beef cattle: A comparative study of high and low residual feed intake bulls
Yi X., Yi S., Wang J., Ye B., Zhu X., Meng Q.
Laboratory Study, published in Anim Nutr (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Anim Nutr (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40896481
- PMCID
- PMC12391812
- DOI
- 10.1016/j.aninu.2025.03.019
Abstract (original English)
This study investigated lipid metabolism differences between low and high residual feed intake (LRFI and HRFI) bulls. Fifty-five Simmental bulls (449.84 ± 8.49 kg) were fed the same diet for 161 d to determine RFI values. At the end of experiment, back fat thickness (BFT) and rib eye area (REA) were measured via ultrasound, and serum samples were collected for lipid metabolism indicators. Post-slaughter, subcutaneous adipose tissue was analyzed for lipid metabolism indicators, histology, transcriptomics, and lipid metabolomics. Results 1) Ultrasound showed LRFI bulls had lower BFT ( P = 0.031) but higher REA ( P = 0.021). 2) Serum total cholesterol ( P = 0.028) and low-density lipoprotein cholesterol ( P = 0.015) were lower in LRFI bulls. Leptin levels were lower in both serum ( P = 0.007) and adipose tissue ( P = 0.001) in LRFI bulls, as were acetyl-CoA carboxylase levels in serum ( P = 0.032) and adipose tissue ( P = 0.043). Conversely, adipose triglyceride lipase levels were higher in both serum ( P = 0.045) and adipose tissue ( P = 0.043), while adipose tissue fatty acid synthase levels were lower ( P = 0.035) in LRFI bulls. 3) Transcriptomics identified two pathways, adenosine monophosphate-activated protein kinase (AMPK) and cyclic adenosine monophosphate (cAMP), involving five lipid metabolism-related genes. Among these, adenylate cyclase activating polypeptide 1 recepto
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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