Do not sleep on vitamin D: vitamin D is associated with sleep variability in apparently healthy adults

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Vitamin D is associated with sleep quality and duration, but it is unclear whether vitamin D status influences sleep variability. Therefore, we sought to determine whether vitamin D status was associated with sleep variability in healthy adults. We assessed objective sleep, including timing and duration standard deviation (SD) using the Philips Actiwatch Spectrum and subjective sleep quality using the Pittsburgh Sleep Quality Index (PSQI) in 130 adults. We measured plasma 25(OH)D concentration to assess vitamin D. We used one-way ANOVAs and Kruskal-Wallis tests to compare sleep in participants characterized as vitamin D deficient ( 30ng/mL). We used covariate-adjusted linear regression to assess associations between vitamin D status and sleep metrics. We compared differences in "low" and "high" sleep variability based on vitamin D status using the Chi-squared test. There was an effect of vitamin D status on sleep timing SD (Kruskal-Wallis, P = 0.021) and sleep duration SD (Kruskal-Wallis, P R 2 = 0.267, P P = 0.050, insufficient vs. sufficient P = 0.022). There was no effect of vitamin D status on objective sleep duration, efficiency, or PSQI scores ( P > 0.05). We did not observe differences in "low" and "high" sleep timing SD based on vitamin D status (χ 2 = 5.43, P = 0.066), but we did for sleep duration SD (χ 2 = 22.4, P NEW & NOTEWORTHY Our findings reveal that individuals

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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