Donor-matched comparison of chondrogenic progenitors resident in human infrapatellar fat pad, synovium, and periosteum - implications for cartilage repair.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Purpose : There is a clinical need to better characterize tissue sources being used for stem cell therapies. This study focuses on comparison of cells and connective tissue progenitors (CTPs) derived from native human infrapatellar fatpad (IPFP), synovium (SYN), and periosteum (PERI). Materials and Methods : IPFP, SYN, PERI were harvested from twenty-eight patients undergoing arthroplasty. CTPs were quantitatively characterized using automated colony-forming-unit assay to compare total nucleated cell concentration-[Cell], cells/mg; prevalence-(P CTP ), CTPs/million nucleated cells; CTP concentration-[CTP], CTPs/mg; proliferation and differentiation potential; and correlate outcomes with patient's age and gender. Results : [Cell] did not differ between IPFP, SYN, and PERI. P CTP was influenced by age and gender: patients >60 years, IPFP and SYN had higher P CTP than PERI ( p < 0.001) and females had higher P CTP in IPFP ( p < 0.001) and SYN ( p = 0.001) than PERI. [CTP] was influenced by age: patients <50 years, SYN ( p = 0.0165) and PERI ( p < 0.001) had higher [CTP] than IPFP; patients between 60 and 69 years, SYN ( p < 0.001) had higher [CTP] than PERI; patients >70 years, IPFP ( p = 0.006) had higher [CTP] than PERI. In patients >60 years, proliferation potential of CTPs differed significantly (SYN>IPFP>PERI); however, differentiation potentials were comparable between all t

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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