Dopaminergic induction of human adipose-derived mesenchymal stem cells is accompanied by transcriptional activation of autophagy.
Hasani S., Boroujeni ME., Aliaghaei A., Baghai K., Rostami A.
Laboratory Study, published in Cell Biol Int (2018) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Cell Biol Int (2018)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 30238552
- DOI
- 10.1002/cbin.11056
- Citations
- 3
Abstract (original English)
Neural differentiation involves drastic morphological alterations, essentially performed by a cell-homeostasis maintaining process known as autophagy. Here, we used the cocktail of choroid plexus epithelial cell-conditioned medium (CPEC-CM) and 15% knockout serum (KS) to induce human adipose-derived mesenchymal stem cells (hASCs) into tyrosine hydroxylase (TH)-positive neuron like cells. We showed that upon this induction, autophagy pathway was transcriptionally triggered. The expression levels of autophagy markers mTOR, BECN1, and MAP1LC3 were evidently changed throughout the dopaminergic (DAergic) differentiation of hASCs, highlighting the critical role of autophagy in this process at the level of transcription.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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