Dual Role of Transcription Factors in the Development and Thermogenic Function of Brown Adipose Tissue
Wang S., Xie F., Li W., Xie W., Cheng H.
Narrative Review, published in Int J Med Sci (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Int J Med Sci (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41799766
- PMCID
- PMC12964565
- DOI
- 10.7150/ijms.127214
Abstract (original English)
Obesity, a major global health challenge, is intricately linked to various metabolic disorders, primarily driven by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT), through its unique thermogenic capability, dissipates energy as heat, playing a vital role in regulating energy homeostasis and maintaining body temperature. Recent studies have revealed a complex regulatory network involving multiple transcription factors (e.g., PPARγ, EBF2, ZFP516, FOXP1) and signaling pathways (e.g., cAMP-PKA, AMPK, mTOR), which act synergistically to finely tune the development and thermogenic function of BAT. Furthermore, gene therapy based on adeno-associated virus (AAV) vectors, which enhances the thermogenic capacity of BAT, provides a highly promising strategy for addressing obesity and metabolic disorders. Additionally, several natural product extracts including Artemisia argyi oil and capsaicin may activate BAT thermogenesis with fewer side effects, representing potential safe and effective dietary supplements for combating obesity in the future. A deeper understanding of these mechanisms may lead to novel therapeutic approaches targeting obesity and metabolic disorders, paving the way for new interventions to improve human health.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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