[Dynamics of osteogenesis after inoculation of autogenic mesenchymal stem cells of adipose tissue].
Grygoryan AS., Orlov AA., Saburina IN., Repin VS., Sisoev SD.
Animal Study, published in Stomatologiia (Mosk) (2015) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Stomatologiia (Mosk) (2015)
- Country
- Russia (Federation)
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 26271694
- DOI
- 10.17116/stomat20159434-8
Abstract (original English)
Experiment was conducted on 40 rats of Wister line. On the artificially reproduced experimental model autogenic mesenchimal stem cells (MSC) of adipose tissue were inoculated in space between bone autograph of tibia and mandible. MSC wasn't inoculated in the comparison group. Formation of a new bone substance in space between an autograph and mandible bone was observed. It was clear that after 120 days (180 days), there was a statistically significant decline of the area occupied by an immature fibroreticular bone. Described phenomenon, presumably, could be explained as a result of decline of the number of active cells in the population of inoculated MSC according to phenomenon of limited number divisions of cells on telomeres, described by Hayflick L. and Moorhead P.S. В эксперименте на 40 крысах линии Вистар 20 крысам основной группы на искусственно воспроизведенной экспериментальной модели, в которой костный аутотрансплантат из большеберцовой кости помещали на поверхности нижнечелюстной кости (материнская кость) и в пространство между ними, инокулировали аутогенные мезенхимальные стволовые клетки (МСК) из жировой ткани. В группе сравнения использовали ту же экспериментальную модель, однако МСК не вводили. В основной группе наблюдалось интенсивное новообразование между аутокостным трансплантатом и материнской костью фиброретикулярных костных структур, которая в последующем пр
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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