Effect of Co-transplanting Stromal Vascular Fraction-Gelatin and Platelet-Rich Fibrin on the Long-Term Maintenance of Fat Volume.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Objective In the present study, we aimed to investigate the survival of stromal vascular fraction-gelatin (SVF-gel) grafts and determine whether co-transplantation of SVF-gel and platelet-rich fibrin (PRF) improves long-term maintenance of fat volume (Wei et al. in Oncotarget 8:68542-68556, 2017) in a rabbit model. Methods SVF-gel was transplanted into the ears of 12 rabbits with (experimental group) or without PRF (control group). Transplantation retention was evaluated based on weight, histology, and immunohistochemistry. Results In the 2nd and 4th weeks, the volume of fat was larger in the experimental group than in the control group. In the 6th week, the absorption of fat was noticeable in both groups, and there was no significant difference in the fat survival rate between the two groups (experimental group: 1.051 ± 0.144 and control group: 0.789 ± 0.232, P > 0.05). HE staining results: At week 2, adipocytes were observed in the experimental group and tended to mature over time. These adipocytes also exhibited an ordered arrangement. Adipocytes with abnormal morphology appeared in the control group in the 4th week. At different weeks, there were more inflammatory cells and fibroblasts in the experimental group than in the control group, and they were arranged in an ordered fashion. Immunohistochemical results: More brown areas were observed in the experimental group than i

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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