[Effect of hypoxia on dedifferentiation of mature adipocytes: an experimental study].
Liao YJ., Gao JH., Jiang P., Lu F.
Prospective Study, published in Nan Fang Yi Ke Da Xue Xue Bao (2008) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Nan Fang Yi Ke Da Xue Xue Bao (2008)
- Country
- China
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 18359685
- Citations
- 2
Abstract (original English)
Objective To study the morphological changes of mature adipocytes in hypoxic condition in vitro and investigate the effect of hypoxia on dedifferentiation of mature adipocytes. Methods Human adipose tissue was collected from individuals undergoing liposuction procedures, from which the stem cells were isolated and induced to become mature adipocytes. After cell culture in hypoxic condition, the adipocytes were observed for morphological changes at different time points. Results After a few days of culture in hypoxic condition, the mature adipocytes derived from the adipose tissue-derived stem cells underwent morphological changes from spherical cells into fibroblast-like cells capable of continuous cell division. Conclusion Mature adipocytes may dedifferentiate into fibroblast-like cells under appropriate conditions.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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