Effect of Intracorporeal Human Adipose-Derived Stem Cells (hADSCs) on Corpora Cavernosa Transforming Growth Factor β 1 (TGFβ 1 ) and Collagen Type I Concentration in Wistar Rat Priapism Model.
Siregar S., Adriansjah R., Sibarani J., Mustafa A.
Laboratory Study, published in Res Rep Urol (2020) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Res Rep Urol (2020)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 32104667
- PMCID
- PMC7008193
- DOI
- 10.2147/RRU.S232303
- Citations
- 8
Abstract (original English)
Introduction The ischemic process in priapism can lead to displacement of normal tissue with fibrotic tissue, due to collagen deposition, and eventually leads to erectile dysfunction. Many studies have identified that the supernatant of adipose tissue-derived stem cells (ADSCs) significantly ameliorates fibrosis of different tissue, but limited attention has been paid to its efficacy on fibrosis of the corpora cavernosa. Methods A total of 22 Wistar rats divided into five groups, with two groups each consisting of five male wistar rats with priapism without human ADSC (hADSC) therapy (group I) and two other groups consisting of five rats with priapism, were given 10 6 cells' intracorporeal hADSC injection after 12 hours of penile clamping (group II) were euthanized after 2 and 4 weeks of observation. The last group consisted of two rats without any treatment or model (group III). Following euthanasia, penises were harvested for TGFβ 1 and collagen type I measurement using ELISA. Statistical analysis using independent-sample t -tests was done with SPSS 21.0. Results Penile TGFβ 1 concentration in the treatment group was significantly lower in the second and fourth weeks of observation ( p 2 =0.004, p 4 =0.003), and collagen type I was significantly lower in the second and fourth weeks ( p 2 =0.003, p 4 =0.011). Conclusion Intracorporeal hADSC injection limited the fibrosis proce
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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