[Effect of pregnant rat adipose-derived stem cells on repair of acute liver injury].
Li J., Chen J., Chen Z., Yang H., Hou K.
Animal Study with a reported sample of 5, published in Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2017) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (2017)
- Country
- China
- Reported sample size
- 5
- Source database
- PubMed
- PMID
- 29806268
- PMCID
- PMC8458118
- DOI
- 10.7507/1002-1892.201610076
Abstract (original English)
To assess the effect of pregnant rat adipose-derived stem cells (ADSCs) on repair of acute liver injury. ADSCs were isolated from 18-week pregnant Sprague Dawley rats and were identified by flow cytometry. Twenty Sprague Dawley rats were randomly divided into groups A, B, C, and D ( n =5); rats in group A were not treated as normal controls; rats in groups B, C, and D were injected intraperitoneally with CCl 4 to establish the acute liver injury model. At 2 hours after modeling, DPBS, 0.1 mL normal rat ADSCs (2×10 6 cells/mL), and pregnant rat ADSCs (2×10 6 cells/mL) were injected into the spleen in groups A, C, and D respectively; rats in group B was not treated. After 7 days, total bilirubin (TBIL), alanine aminotransferase (ALT), aspartic acid transaminase (AST), albumin (ALB), and total protein (TP) in serum were measured. The liver tissue sections were stained with HE. The expressions of Ki67, alpha-fetoprotein (AFP), and ALB were measured by immunohistochemistry. The serum levels of TBIL, ALT, and AST in group B were significantly higher than those in groups A, C, and D ( P <0.05), but ALB and TP were significantly lower than those in groups A, C, and D ( P <0.05). The levels of TBIL, ALT, and AST were significantly higher in groups C and D than group A, and in group C than group D ( P <0.05). There was no significant difference in serum levels of ALB among groups A, C, a
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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