The effect of therapeutic potential and safety of bone marrow-derived against adipose-derived mesenchymal stem cells in aged mice associated with septic arthritis.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Mesenchymal stem cells (MSCs) show potential for treating septic arthritis in aged populations, but their efficacy and safety in aged patients remain unclear. The objective of this study is to evaluate the therapeutic potential and safety profiles of bone marrow-derived MSCs (BM-MSCs) and adipose-derived MSCs (AD-MSCs) in aged murine model of septic arthritis. MSCs were isolated, characterized, and labeled for in vivo tracking. The experiment consisted of a total of 36 mice, which included 9 subgroups with four replicates per treated group: control group, treated groups (BM-MSC1, BM-MSC2, AD-MSC1, and AD-MSC2), and untreated groups (Un-BM1, Un-BM2, Un-AD1, and Un-AD2). The treated groups received MSC therapy following the induction of septic arthritis via intra-articular injection of Staphylococcus aureus. The results showed that BM-MSC1 significantly performed higher than AD-MSCs in reducing inflammation, promoting cartilage repair, and modulating immune responses. BM-MSC1 showed significant upregulation of regenerative markers such as interleukin-10 (IL-10) and collagen type II alpha 1 chain (COL2A1) and downregulation of pro-inflammatory markers such as tumor necrosis factor-alpha (TNF-a) and matrix metalloproteinase-13 (MMP-13). Imaging confirmed superior retention, engraftment, and host tissue interaction for BM-MSCs. AD-MSCs showed slightly lower efficacy and safety, high

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.