Effectiveness of regenerative medicine for skin lightening and rejuvenation: a systematic review of extracellular vesicles and conditioned media

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Aims and objectives This study aims to evaluate and summarize the efficacy and safety of extracellular vesicles (EVs) and conditioned media (CM) as emerging therapeutic approaches in regenerative medicine for skin rejuvenation and lightening. Methods A systematic search was conducted up to September 19, 2024, using the PubMed, Scopus, and Web of Science databases. Keywords included "conditioned media," "secretome," "extracellular vesicles," "exosome," "rejuvenation," "lightening," and others. Studies were screened based on predefined inclusion criteria, followed by data extraction. Key extracted data included study design, population characteristics (mean age and range), intervention duration, comparisons, outcomes with statistical results, and adverse effects. The statistical methods applied in individual studies were documented to assess the validity of reported improvements. Results This review included 19 studies with a total of 624 patients evaluating the efficacy and safety of EVs and CMs for skin lightening and rejuvenation. Among these, 21% investigated the effects of EVs, while 78% focused on CMs. The most commonly assessed skin parameters included wrinkles, pigmentation, spots, elasticity, and hydration. Various application methods were used, including topical administration, microneedling, and fractional laser therapy. Reported improvements included a 27.07% increase

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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