Effects of Adipose-Derived Stem Cell Extract on Peripheral Nerve Cells.
Imai Y., Kishimoto N., Koyama Y., Sango K., Takeuchi K., Yamazaki M.
Laboratory Study, published in Cureus (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Cureus (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41209978
- PMCID
- PMC12595584
- DOI
- 10.7759/cureus.94180
Abstract (original English)
Adipose-derived stem cells (ADSCs) can be obtained from adipose tissue, which is considered clinically dispensable. ADSCs have the ability to differentiate not only into adipocytes and osteoblasts but also into various other cell types, such as nerve cells and cardiomyocytes. However, the clinical application of ADSCs in stem cell therapy is hampered by the risk of transplant rejection and the need for facilities for their storage and transportation. In comparison, cell extracts (CEs) obtained from stem cells by freeze-thawing and lysis are less tumorigenic and immunogenic. However, there are currently no studies on the application of ADSC-derived CEs (ADSC-CEs) in peripheral nerve regeneration. Therefore, in this study, we investigated the effects of ADSC-CEs on proliferation and neurite extension in peripheral nerve cells. ADSCs were harvested from the inguinal region of mice, and ADSC-CEs were obtained following repeated freeze-thawing of ADSCs. We examined the effects of the ADSC-CEs, added to the culture medium, on glial fibrillary acidic protein (GFAP) expression and proliferation in Schwann cells. Moreover, we examined the effects of the ADSC-CEs on neurite length in DRG neurons and PC12D cells. ADSC-CEs stimulated the proliferation of Schwann cells, elevated GFAP expression in these cells, and promoted the elongation of DRG neuron and PC12D cell projections. Notably, he
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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