Effects of adipose-derived stem cells on improving the viability of diced cartilage grafts.
Orbay H., Tobita M., Hyakusoku H., Mizuno H.
Animal Study, published in Plast Reconstr Surg (2012) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Plast Reconstr Surg (2012)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 21987040
- DOI
- 10.1097/PRS.0b013e31822b65fd
- Citations
- 11
Abstract (original English)
Diced cartilage grafts are useful for dorsal nasal augmentation; however, long-term resorption usually occurs. The aim of this study was to examine the effects of adipose-derived stem cells on the viability of diced cartilage grafts. Twenty Fischer rats were divided into four groups with diced cartilage grafts wrapped in the following components: abdominal fascia (group I), Surgicel (group II), abdominal fascia plus adipose-derived stem cells (group III), or Surgicel plus adipose-derived stem cells (group IV). Grafts were placed subcutaneously along the dorsal midline, and the weights were recorded both before implantation and after explantation. Histologic examination was performed after 8 weeks using hematoxylin and eosin, safranin O, van Gieson, glial fibrillary acid protein, and von Willebrand factor immunofluorescence staining. The percentage reduction in weight, indicating resorption, was significantly lower in group III (p < 0.01). Both the number of nucleated lacunae per unit area and the proteoglycan content were significantly higher in group III compared with the other groups (p < 0.05). Elastic fibers around the regenerating cartilage islands were seen by van Gieson staining in the fascia groups but not in the Surgicel groups. Glial fibrillary acid protein was also significantly higher in group III (p < 0.01). There was no statistically significant difference in vasc
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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