Effects of calcium, fucoidan and chitooligosaccharide supplementation on bone mineral density and calcium balance in ovariectomized rats
Yun S., Choi MK., Kim MH.
Laboratory Study, published in Nutr Res Pract (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Nutr Res Pract (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41377605
- PMCID
- PMC12688000
- DOI
- 10.4162/nrp.2025.19.6.880
Abstract (original English)
Background/objectives This study examined the effect of calcium (Ca), fucoidan, and chitooligosaccharide supplementation alone and in combination on bone mineral density (BMD), bone metabolism, and Ca balance in ovariectomized (OVX) rats. Materials/methods Forty-eight female Wistar rats (6 weeks) were used in this study; among them, 40 rats were OVX, and the rest of the rats were sham-operated (sham). The sham group and one OVX group were fed a standard diet (AIN-96, Ca 0.5%), and the remaining OVX groups received either a fucoidan-supplemented diet (fucoidan 0.05%; OVX-Fu), a chitooligosaccharide-supplemented diet (chitooligosaccharide 0.5%; OVX-Chito), a seaweed Ca-supplemented diet (Ca 1.5%; OVX-Ca), or a fucoidan, chitooligosaccharide and seaweed Ca-supplemented diet (fucoidan 0.05%, chitooligosaccharide 0.5%, Ca 1.5%; OVX-CaFuChito) for 12 weeks. Results The OVX-CaFuChito group had the highest feed intake, but had a significantly lower final body weight than the other groups in OVX rats. The Ca retention was significantly higher in the OVX-Ca and OVX-CaFuChito groups than in all the other groups ( P Conclusion These results suggest that only the combined supplementation of Ca, fucoidan, and chitooligosaccharides may have a beneficial effect on preserving BMD along with suppressing postmenopausal weight gain.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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