Effects of <i>Alpinia oxyphylla</i> stems and leaves extracts on immune function, antioxidant function, and microbial flora composition in the intestinal tract of Jiaji ducks

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Alpiniae Oxyphyllae ( A. oxyphylla ) has been widely used as a traditional herbal medicine, and our previous studies have shown that its extracts from stems and leaves have a beneficial role in Jiaji ducks health. This study aimed to further investigate the effects of the Alpinia oxyphylla stems and leaves extracts (AOE) on the intestinal health of fattening Jiaji ducks. Four hundred and eighty 42-day-old Jiaji ducks were randomly allocated and equally divided into four treatment groups. The control group (CK) was fed a basal diet, and the AOE groups (groups Y1, Y2 and Y3) were fed with supplement 30, 80, or 130 mg/kg of AOE diets for 49 days. The results showed that the stems and leaves of A. oxyphylla contain abundant anti-inflammatory and antioxidant compounds, such as fatty acyls, terpenoids, flavonoids, and phenols. Compared with the CK group, the AOE groups (Y1, Y2, and Y3) exhibited significant effects in the immune and antioxidant functions. Among them, the mRNA expression of interleukin-10 ( IL-10 ), heme oxidase-1 ( HO-1 ) and nuclear factor E2-related factor 2 ( Nrf2 ) in jejunal mucosa was significantly up-regulated ( p = 0.005, p = 0.007, p = 0.005) in the AOE groups (Y1, Y2, and Y3). The levels of lysozyme, intestinal alkaline phosphatase (AKP), glutathione peroxidase (GSH-Px) and anti-superoxide anion radical (ASA) were markedly increased ( p Ruminiclostridium_9

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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