Effects of low-intensity electrical stimulation and adipose derived stem cells transplantation on the time-domain analysis-based electromyographic signals in dogs with SCI.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Introduction The application of low-intensity electrical stimulation (LIES) to neural tissue increases neurochemical factors responsible for regeneration as nerve growth factor. Stem cell (SC) therapy for patients with Spinal cord injury (SCI) promote some increase functional improvement. Objective Investigate the electromyographic response in paraplegic dogs undergoing LIES and SC transplantation. Methods 27 dogs paraplegics with SCI were divided into three groups with different types of therapy. G ADSC : two SC transplants (n = 9); G LIES : LIES (n = 8); G COMB : two SC transplants and LIES (n = 10). Adipose derived mesenchymal stem cells (ADSCs) were transplanted by lumbar puncture in the amount of 1.2 × 10 6 cells/50 μL. Acupuncture needles positioned in the interspinous space were used for stimulation. The electrical stimulation was applied with a mean voltage ∼30 mV and four consecutive modulated frequencies (5 Hz, 10 Hz, 15 Hz and 20 Hz) within 5 min each. The patients motor performance was evaluated before (Pre) the procedure and after 30 (Post 30 ) and 60 (Post 60 ) days, from electromyography root mean square (EMG RMS ) registered with subcutaneous electrodes in the vastus lateralis muscle, while the animals were in quadrupedal position. Results All three groups showed a significant intra-group increase of EMG RMS (Pre vs. Post 30 or Pre vs. Post 60 ). However, there

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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