The Effects and Mechanisms of Low-Intensity Pulsed Ultrasound on Bone Remodeling: From Laboratory to Clinic
Zong B., Sun W., Cai C., Shang P.
Narrative Review, published in Biomolecules (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Biomolecules (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41154580
- PMCID
- PMC12564196
- DOI
- 10.3390/biom15101351
- Citations
- 2
Abstract (original English)
Decades of research and applications have demonstrated that low-intensity pulsed ultrasound (LIPUS) has a certain therapeutic effect on diseases involving bone remodeling. LIPUS operates in a pulsed-wave mode at low intensity, ensuring efficient transmission of acoustic energy to target tissues, thereby providing non-invasive physical stimulation for therapeutic purposes. Bone remodeling refers to the dynamic renewal process of bone tissue that is jointly completed by multiple cells in the bone metabolic microenvironment. LIPUS influences the basic biological processes of bone remodeling in the skeletal system through mechanical, piezoelectric, and thermal effects on bone tissue, triggering a series of biochemical reactions. This article begins with the discovery of ultrasound and research on bone remodeling, introduces the basic parameters and application devices of LIPUS, and reviews the clinical applications of and basic research on LIPUS in bone remodeling disorders. Focusing on the intersection and integration of biomedical fundamentals and ultrasound science, it analyzes the biological and physical mechanisms of LIPUS in research on and applications of bone remodeling disorders and investigates the basic research questions and clinical transformation application scenarios in this field.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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