The effects of testicular aging on Leydig cells and the application of stem cells in restoring Leydig cells function
Zhu WB., Zhao HB., Wang GZ., Wang ZL., Wang SQ.
Narrative Review, published in Reprod Biol Endocrinol (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Reprod Biol Endocrinol (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41257884
- PMCID
- PMC12628551
- DOI
- 10.1186/s12958-025-01487-9
- Citations
- 2
Abstract (original English)
With the global population aging at an accelerated pace, testicular aging and its associated male health issues have garnered increasing attention. Testicular aging encompasses both age-related physiological decline and premature or pathological aging caused by various pathogenic factors. It is primarily characterized by reduced androgen secretion (mainly testosterone) and impaired spermatogenesis. Leydig cells, the key cells in the testes responsible for synthesizing and secreting testosterone, play a critical role in maintaining testicular function, and their dysfunction is one of the major contributors to testicular functional decline. In recent years, stem cell technology has demonstrated significant potential in restoring Leydig cell function. Stem cells possess the ability to differentiate into Leydig-like cells, which can restore testosterone secretion, improve the testicular microenvironment, and promote the regeneration of endogenous Leydig cells. Currently, various types of stem cells, such as stem leydig cells, mesenchymal stem cells, and induced pluripotent stem cells, have been successfully directed to differentiate into Leydig-like cells. This article provides an in-depth analysis of the mechanisms by which testicular aging affects Leydig cells, with a particular focus on the application of stem cell technology in restoring Leydig cell function. Additionally, it e
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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