Efficacy of Polynucleotide for the Recovery of Depressed Lesions Following Steroid-Based Lipolysis Injections

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Steroid-containing lipolysis injections may rarely induce facial lipoatrophy, resulting in persistent contour deformities and psychological distress. In compromised tissues, conventional fillers may pose safety concerns, prompting interest in treatment approaches that support local tissue recovery. Objective To evaluate the clinical efficacy and safety of polynucleotide (PN) injection for facial lipoatrophy caused by steroid-containing lipolysis injections. Methods This retrospective clinical study included six patients who developed facial lipoatrophy following steroid-containing lipolysis injectionsand were treated with PN (Rejuran ® , 20 mg/mL). PN was administered using a combination of intradermal microinjections and superficial subcutaneous bolus injections at 2-4-week intervals. Clinical outcomes were assessed using the Physician's Global Assessment (PGA; 1-5 scale) based on standardized photographic comparisons, along with patient-reported satisfaction. Results All patients demonstrated meaningful improvement in facial contour following PN treatment. Three patients achieved near-complete resolution (PGA 5), while the remaining three showed substantial improvement (PGA 4). Improvement progressed gradually with repeated sessions. No treatment-related adverse events were observed. Conclusion PN injection appears to be a safe and effective tissue-supportive optio

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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