Efficacy of Stromal Vascular Fraction for Scar Prevention: A Multicenter, Double-Blinded, Randomized Controlled Trial.

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Addressing postoperative scarring remains a significant challenge across all surgical procedures, often leading to long-term aesthetic deficits. Traditional methods for scar management have shown limited efficacy, prompting exploration into innovative approaches such as the application of stromal vascular fraction (SVF). Objectives The efficacy of intraoperative SVF injection in modulating scar formation was assessed by evaluating postoperative scar quality in patients undergoing free tissue transfer. Methods This multicenter, double-blinded, placebo-controlled, randomized study assessed the efficacy of intraoperative SVF injections in mitigating scar formation in patients undergoing free tissue transfer. A total of 45 patients were enrolled from three institutions, undergoing either breast reconstruction with abdominal flaps or soft tissue reconstruction with anterolateral thigh flaps. The donor site incision was split in half, with one side receiving SVF injections and the other saline injections, assigned randomly. Scar quality was evaluated using the Vancouver Scar Scale (VSS) and Patient Scar Assessment Questionnaire (PSAQ), along with objective measures of pigmentation using an analyzing device. Results The primary analysis endpoint at 6 months after surgery showed a statistically significant improvement in VSS scores in the SVF group compared to the saline gro

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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