From elective protocols to emergency reality: rethinking adipose tissue harvesting for stromal vascular fraction applications.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Adipose tissue is a readily accessible source of stromal vascular fraction (SVF) and adipose-derived stem/stromal cells, widely used in regenerative medicine. Current harvesting and processing standards are derived almost exclusively from elective surgical settings performed under controlled physiological conditions. However, expanding applications in trauma and neurosurgery increasingly require adipose tissue procurement in emergency settings, where systemic inflammation, hypoperfusion, and time constraints may alter tissue biology. The biological impact of emergency harvesting remains insufficiently characterized, yet this knowledge is critical for optimizing SVF-based regenerative medicine strategies in emergency surgical environments. Objectives To evaluate how emergency adipose procurement may influence SVF quality, cellular yield, viability, and translational feasibility, and to propose an acute-care-adapted framework for clinical integration. Methods A comprehensive search of PubMed, EMBASE, and Scopus (inception-January 2026) identified studies addressing harvesting techniques, donor-site variability, enzymatic vs mechanical isolation, time-to-processing effects, cryopreservation, contamination risk, and clinical outcomes. Data were synthesized narratively with emphasis on variables relevant to emergency settings. Results Harvesting parameters-including cannu

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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