Electrospun antimicrobial poly(lactic acid) foams with nanocellulose for enhanced hydrophilicity and controlled drug release
Sleinus D., Lovato MJ., Platnieks O., Sabalina A., Gaidukovs S., Franco L.
Laboratory Study, published in RSC Adv (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- RSC Adv (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40027584
- PMCID
- PMC11869570
- DOI
- 10.1039/d4ra08580a
- Citations
- 4
Abstract (original English)
This study explores an advanced approach to enhancing the antimicrobial efficacy and hydrophilicity of poly(lactic acid) (PLA) scaffolds through the strategic incorporation of cellulose nanocrystals (CNC). The compatibility between these biodegradable polymers was investigated to optimize antimicrobial agent release while preserving structural integrity. PLA nanocomposites incorporating the antimicrobial agents curcumin (Cur) or polyhexamethylene biguanide (PHMB) were fabricated using three distinct electrospinning-based methodologies. The antibacterial properties were assessed via a disc diffusion test against five bacterial strains: Escherichia coli , Escherichia coli B+, Lactobacillus salivarius , Streptococcus sanguinis , and Streptococcus mutans . In addition, drug release experiments were conducted to determine the diffusion kinetics in a simulated blood serum medium, demonstrating sustained drug release for up to 98 hours. PHMB demonstrated potent antibacterial activity, while curcumin primarily exhibited bacteriostatic effects. The thermal stability of the nanocomposites exhibited an increase of up to 41 °C in the maximum degradation temperature. The mechanical properties were assessed to further examine the interactions between CNC and PLA and the possibility to reshape the materials for different delivery approaches. The findings underscore the crucial role of CNC in
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.