Electrospun Polycaprolactone Nanofibers: Current Research and Applications in Biomedical Application
Azari A., Golchin A., Mahmoodinia Maymand M., Mansouri F., Ardeshirylajimi A.
Narrative Review, published in Adv Pharm Bull (2022) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Adv Pharm Bull (2022)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 36415646
- PMCID
- PMC9675923
- DOI
- 10.34172/apb.2022.070
- Citations
- 58
Abstract (original English)
Unique mechanical properties, miscibility potency, and biodegradability are the three prominent features of polycaprolactone (PCL), making it an attractive biomaterial which commonly applied in regenerative medicine and biomedical engineering. Different strategies developed for fabricating nanofibrous construct, electrospinning is a practical, simple, and efficient technique based on electro-hydrodynamic systems that use an electrified viscous fluid jet drawn by the air toward a collector at a changing electric potential. PCL electrospun-based nanofibrous composites as proper scaffolds are employed in stem cell-related research, particularly in tissue engineering, wound dressing, and systems designed for sending drugs. A compilation of mechanochemical properties and most common biological performance on PCL-based electrospun fibrous structures in biomedical application are included in this study. Therefore, electrospun PCL nanofiber applying has been presented, and after that, current progress and prospects have been discussed. Literature reviews revealed that electrospun PCL nanofibrous composites had gained significant attention in regenerative medicine, and these structures have shown notable development in mechanobiological properties. This evidence is a crucial success for biomedical strategies, especially in regenerative medicine.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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