Emerging regenerative strategies for spinal cord injury: exosome-derived mechanisms and therapeutic insights

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Spinal cord injury (SCI) often leads to severe motor and sensory impairments, and current treatment methods have not achieved complete neural repair. In recent years, exosomes have become a research focus in the treatment of nerve injuries due to their important roles in intercellular information transfer, immune regulation, and neural repair. Our study conducts a scientometric analysis to map the research landscape related to exosomes in SCI. Methods Articles and reviews related to exosome in SCI were retrieved from the Web of Science Core Collection and Scopus. Analysis was conducted using Microsoft Excel 2021, CiteSpace (6.4.R1), VOSviewer (1.6.18), the R software (4.4.3) bibliometrix package, etc. Results Since 2018, the number of publications has rapidly increased. Fan Jin is the most academically influential author in the field, while Cai Weihua's research has received widespread recognition from researchers. China is the leading contributor among the 32 countries/regions. Among the 708 institutions, Central South University and Zhejiang University are the primary supporters. Journal of Nanobiotechnology is the most influential journal in this field, with Neural Regeneration Research and Cells also making significant contributions. Keyword analysis focuses on "mesenchymal stem cells," "inflammation," "cell therapy," "axonal regeneration," "functional recovery,"

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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