Emerging ultrafast technologies in biotechnology
Jahan I., Harun-Ur-Rashid M., Almuhayawi MS., Al Jaouni SK., Selim S.
Narrative Review, published in 3 Biotech (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- 3 Biotech (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40292246
- PMCID
- PMC12021753
- DOI
- 10.1007/s13205-025-04309-2
- Citations
- 2
Abstract (original English)
This review highlights the transformative applications of ultrafast technologies in biotechnology, focusing on their ability to provide real-time visualization and precise manipulation of biomolecular processes. Femtosecond lasers have enhanced precision in gene editing, minimizing off-target effects, while ultrafast spectroscopy has advanced understanding of protein folding pathways, enzymatic activity, and energy transfer mechanisms. Notable findings include the identification of protein folding intermediates linked to misfolding diseases, improved insights into enzymatic catalysis through hydration studies, and the development of real-time monitoring systems for CRISPR gene editing. Imaging innovations such as pump-probe microscopy and Coherent Anti-Stokes Raman Scattering (CARS) enable high-resolution observation of cellular dynamics, intracellular signaling, and neural activity. Furthermore, attosecond spectroscopy has provided unprecedented insights into ultrafast electron dynamics and charge migration. Integrating ultrafast technologies with AI and nanotechnology has accelerated advances in diagnostics, personalized medicine, and synthetic biology, driving breakthroughs in drug discovery, targeted therapeutics, and regenerative medicine. Despite challenges such as photodamage, integration with complex biological systems, and ethical considerations, ongoing advancements i
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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