Engineering principles of zwitterionic hydrogels: Molecular architecture to manufacturing innovations for advanced healthcare materials
Bui HL., Nguyen HN., Lai JY., Huang CJ.
Narrative Review, published in Mater Today Bio (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Mater Today Bio (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40704012
- PMCID
- PMC12284511
- DOI
- 10.1016/j.mtbio.2025.102085
- Citations
- 4
Abstract (original English)
Zwitterionic hydrogels have garnered significant attention for their exceptional anti-fouling properties and biocompatibility. These materials have been further enhanced through the incorporation of highly crosslinked 3D networks, endowing them with novel physicochemical characteristics such as stimuli-responsive swelling, ion conductivity, and antibacterial capabilities. In certain cases, zwitterionic motifs can impart self-healing properties for hydrogels, potentially paving the way for the development of functional biomaterials that closely mimic biological tissues. In recent years, we have witnessed substantial efforts from the scientific community to harness the potential of zwitterionic hydrogels for various biomedical applications. This review offers a comprehensive examination of the design principles underlying these materials, spanning from molecular engineering aspects to recent advancements in synthesis routes and fabrication methods. The discussion encompasses the advantages and limitations of different preparation processes, as well as prospects for zwitterionic hydrogels. As a result, this review aims to provide valuable insights for researchers and engineers working to optimize zwitterionic hydrogels for specific biomedical applications, including drug delivery, tissue engineering, and biosensors.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.