Enhanced osteoconductivity of green synthesized hydroxyapatite-functionalized Nd2O3/Fe3O4 nanocomposite using Elaeagnus angustifolia L. seed extract.
Salari E., Sadeghzadeh H., Valizadeh N., Kazeminava F., Jafarirad S., Salehi R.
Laboratory Study, published in Stem Cell Res Ther (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Stem Cell Res Ther (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41194149
- PMCID
- PMC12590608
- DOI
- 10.1186/s13287-025-04676-w
Abstract (original English)
This study describes the green synthesis of a neodymium oxide/magnetic iron oxide (Nd 2 O 3 /Fe 3 O 4 ) nanocomposite, functionalized with hydroxyapatite, using Elaeagnus angustifolia L. seeds extract. Then the effectiveness of electrospun polycaprolactone-collagen (PCL-COL) loaded with nanoparticles composites as scaffolds for bone tissue engineering was evaluated. The synthesis of nanoparticles and their elemental identification were confirmed using XRD, FT-IR, and EDX techniques. The DLS, TEM, and SEM analysis demonstrated the generation of Nd-Fe 3 O 4 @HAp NPs with an average diameter of 14-18 nm. Vibrating Sample Magnetometry (VSM) validated the ferromagnetic and superparamagnetic characteristics of the nanoparticles. Tensile and contact angle analysis revealed that NP-loaded electrospun scaffolds exhibited markedly enhanced mechanical characteristics and hydrophilicity relative to pristine polymer specimens, owing to the homogeneous distribution of nanofillers throughout the polymer fibers. Additionally, cellular investigations and osteogenic potential were evaluated in vitro using adipose-derived mesenchymal stem cells (ADMSCs). Assessments of cell attachment, spreading, and proliferation of ADMSCs were conducted using SEM observation and thiazolyl blue (MTT) test. The osteogenic differentiation potential of ADMSCs on the fabricated nanofiber scaffolds was evaluated usin
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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