Enhanced osteogenicity of adipose tissue-derived stem cells induced by phytochemically synthesized Fe 3 O 4 /Lanthanum/SiO 2 nanocomposite using ulmus minor Mll. extract.
Badri KR., Jafarirad S., Sadeghzadeh H., Valizadeh N., Salehi R.
Laboratory Study, published in J Biol Eng (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Biol Eng (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40890805
- PMCID
- PMC12403322
- DOI
- 10.1186/s13036-025-00540-w
Abstract (original English)
In this study, nanofibrous scaffolds composed of Polycaprolactone/Collagen (PCL/COL) infused with Fe 3 O 4 /Lanthanum/SiO 2 nanocomposite were developed. Fe 3 O 4 and La-doped Fe 3 O 4 nanoparticles were synthesized using a straightforward co-precipitation method. Silica extracted from Ulmus leaves via green synthesis was used to coat the Fe 3 O 4 -La nanocomposite. Then, PCL/COL nanocomposite scaffolds entrapping nanocomposites were created by electrospinning and characterized through FT-IR, VSM, EDX, DLS, TEM, FE-SEM, XRD, tensile strength, and contact angle techniques. The study comprehensively assessed their impacts on physical, mechanical, chemical, and biological attributes to evaluate their suitability for bone regeneration applications. The results revealed that the Fe 3 O 4 -La and Fe 3 O 4 -La@SiO 2 magnetic nanoparticles were synthesized at the nanoscale (64.3 and 83.6 nm), exhibiting superparamagnetic properties and a spherical morphology. The addition of MNPs enhanced the hydrophilicity and mechanical characteristics of the PCL/COL nanofibers. ADSCs were cultured onto nanocomposite scaffolds and the ALP activity, calcium mineralization, and the expression of bone-related proteins (such as Runx2, OCN, ON, and BMP2) were significantly increased in cells cultured on PCL/COL-MNPs nanofibers compared to PCL/COL scaffold and control groups. Nanocomposite scaffolds signif
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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