Enhancing the differentiation and maturation of adipose derived mesenchymal stem cells into neuronal cells through the sustained nerve growth factor delivery by chitosan nanocarrier.
Gupta A., Choudhary P., Kumar U., Agarwal V., Singh S.
Prospective Study, published in Int J Biol Macromol (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Int J Biol Macromol (2025)
- Country
- Netherlands
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40473178
- DOI
- 10.1016/j.ijbiomac.2025.144891
- Citations
- 4
Abstract (original English)
Neurotrophins, a type of growth factor, are key players in guiding mesenchymal stem cells (MSCs) towards becoming neurons. Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) are well-known for promoting axon growth and pushing MSCs to resemble neural precursor cells. However, their short half-life has consistently generated issues related to their bioavailability, which is essential in determining the fate of stem cells during differentiation. Currently, we have developed a chitosan nanocarrier infused with NGF to enhance its availability in the stem cell niche. Additionally, it is combined with BDNF to formulate a neural induction medium that facilitates the neural differentiation of ADMSCs (Adipose-derived MSCs). The developed cells displayed a morphological appearance consistent with neurological lineage cells, confirmed by the presence of cellular markers linked to neural cells and synaptic connections. The statistical study confirmed that encapsulated NGF is a substantial neural inducer compared to neurotrophin employed alone in the induction medium. The chitosan nanocarrier exhibited advantageous NGF loading efficiency and release kinetics, making it suitable for enhancing neural differentiation. Consequently, the continuous release of NGF via chitosan nanocarriers has enhanced the promotion of neurogenic differentiation of ADMSCs and holds prospective
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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