Enhancing fat graft retention through adipose tissue browning: a systematic review.
Qiu H., Wang H., Ji Q., Wu D.
Systematic Review, published in Stem Cell Res Ther (2025) — summary generated from the PubMed abstract.
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Systematic Review
- Journal
- Stem Cell Res Ther (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40598602
- PMCID
- PMC12220036
- DOI
- 10.1186/s13287-025-04473-5
- Citations
- 1
Abstract (original English)
Background Recently, existing researches have gradually recognized the critical biological behaviour played by spontaneous or exogenous-induced browning conversion in fat transplantation. However, no comprehensive review explored the fat grafts remodeling process toward browning and such role in fat graft retention. Aims This study aimed to elucidate the behavioral characteristics of browning changes following fat grafting, as well as its benefits and mechanisms on the survival of transplanted fat. Methods Databases including Web of science, PubMed, Ovid medline, and Embase were searched from inception through September 2024. Studies related to fat grafts browning in fat transplantation were systematically reviewed, in accordance with the inclusion and exclusion criteria. Results We evaluated 14 studies including 13 animal works and one clinical report. Five studies directly transplanted fat without any browning induction, while others utilized either beige fat or pre-treated grafts with browning stimuli.Data shown that around the periphery of fat grafts (predominantly in survival zone), early accumulations of graft browning can be observed, dynamically accompanying the stable remodeling of the graft. Post-transplantation spontaneous browning typically begins around day 7, stabilizes after approximately 3 months, and may revert to white adipose tissue. The favorable browning up
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
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