Epigenetic regulation of adipogenesis on dental stem cells: a focus on histone modifications.
Montero-Del-Toro JA., Serralta-Interian AA., Torres-Romero JC., Rojas-Herrera R., Rodas-Junco BA.
Narrative Review, published in Mol Biol Rep (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Mol Biol Rep (2026)
- Country
- Netherlands
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41661344
- DOI
- 10.1007/s11033-026-11536-0
Abstract (original English)
Dental stem cells (DSCs) have emerged as valuable tools in regenerative medicine due to their ability to differentiate into various cell types, including adipocytes. Although their adipogenic potential is generally described as modest or lower compared with mesenchymal stem cells from other sources, DSCs remain useful in vitro models for studying the mechanisms underlying adipose tissue formation. This review highlights recent advances in the epigenetic regulation of adipogenesis, including insights from histone modifications, particularly H3K9, which we contextualize within the broader landscape of epigenetic regulation in DSCs and other mesenchymal stem cells (MSCs). Additionally, the effects of epigenetic drugs are analyzed, and differences in adipogenic commitment among various types of DSCs are discussed. These findings underscore their importance as models for designing therapies targeting metabolic diseases.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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