Evaluating the Effect of Hypoxia on Adipose-Derived Mesenchymal Stromal Cells In Vivo: A Systematic Review.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Adipose-Derived Mesenchymal Stromal Cells (ADMSCs) are a developing area of cell therapy due to their ease of access and differentiation potential. Within in vitro studies, culturing cells at low oxygen tension (< 21%) can modulate the immune function of MSCs, enhance cell proliferation, and reduce cell senescence. This could impact their clinical utility when implanted in vivo. This systematic review examined the effect of hypoxic culture on ADMSCs in vitro and their behaviour when implanted into an in vivo disease model. This systematic review was registered on the PROSPERO database with the identification number CRD42023401755. A literature search was performed across four databases: EMBASE, MEDLINE, PubMed, and Cochrane. 320 studies were extracted from Embase, 122 from Medline via Ovid, and no studies were selected from the Cochrane database. Before screening the abstracts, 50 records were removed as duplicates. Following the abstract screening, 330 records were excluded from the search. Based on the complete text, 62 papers were included according to the applied criteria, as shown in Table 1. The final number of included articles was five. In several selected studies, hypoxic culture (or preconditioning) of ADMSCs has been shown to positively affect motility, promoting cell differentiation and the resolution of ischaemic injury. However, hypoxic culture was not universally

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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