Evaluation of anti-oxidant and anticancer effect of marine algae Cladophora glomerata in HT29 colon cancer cell lines- an in-vitro study
Sundaramoorthy S., Dakshinamoorthi A., K C.
Laboratory Study, published in Int J Physiol Pathophysiol Pharmacol (2022) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Int J Physiol Pathophysiol Pharmacol (2022)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 36741197
- PMCID
- PMC9890206
- Citations
- 4
Abstract (original English)
Background Marine algae are a huge Pandora's box of rich nutrients and huge medicinal compounds. These therapeutic compounds are investigated widely for their anticancer, antioxidant, and anti-diabetic properties. Objectives This study aims to evaluate the antioxidant and anticancer effect of the marine algae Cladophora glomerata (collected from Hare Island-Tuticorin region) on HT-29 colon cancer cell lines. Methodology The marine algae, Cladophora glomerata , was collected, processed, and authenticated. Methanol, Ethyl acetate, Chloroform, and Hexane extracts were prepared using a hot solvent extraction process. These extracts were subjected to SOD assay and MTT assay. 5 Fluorouracil was used as the positive control. Results The antioxidant activity of the SOD assay was found to be 85.66±0.81, 80.10±1.25, and 98±0.93 U/mg protein for methanol, ethyl acetate, chloroform, and hexane extracts, respectively. L-Ascorbic acid was used as the positive control whose SOD antioxidant value was found to be 139±1.24 U/mg protein. The IC50 value of methanol, ethyl acetate, chloroform, hexane algae extracts, and 5 Fluorouracil against HT29 cell lines was calculated to be 28.46±0.65, 48.56±1.19, 93.7±0.91, 88.53±0.83, and 8.2±1.3 μg/ml, respectively. Conclusion From the above study, we can infer that the methanol extracts of the algae Cladophora glomerata have excellent anticancer activity.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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