Evaluation of Different Geometry Poly(L-Lactide-Co-Glycolide-Co-Trimethylene Carbonate Oligomer) Scaffolds Fabricated by Material Extrusion 3D Printing for Adipose Derived Stem Cells Culture.
Paduszyński P., Włodarczyk J., Rok J., Pastusiak M., Rzepka Z., Ochab A.
Laboratory Study, published in J Biomed Mater Res B Appl Biomater (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Biomed Mater Res B Appl Biomater (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40259783
- DOI
- 10.1002/jbm.b.35580
- Citations
- 1
Abstract (original English)
The combination of stem cells, growth factors, and biomaterials has driven significant advancements in tissue engineering. Depending on the specific tissue requiring regeneration, the scaffold structure and cell type must be carefully selected. Adipose-derived stem cells (ADSC) have garnered considerable interest due to their ease of isolation and high differentiation potential. However, cellular components alone are often insufficient for complete tissue regeneration, making the selection of an appropriate scaffold structure a critical factor. Modern additive manufacturing techniques enable the precise design and fabrication of scaffolds with tailored properties and architectures. This study presents comprehensive research in tissue engineering, polymer chemistry, and polymer processing, focusing on the fabrication of scaffolds with varying architectures for ADSC culture using additive manufacturing. A poly(L-lactide-co-glycolide-co-trimethylene carbonate oligomer) (PLGA-oTMC) terpolymer of defined molar composition and microstructure was synthesized and processed into a filament suitable for 3D printing via the Material Extrusion (formerly Fused Deposition Modeling) method, which has not yet been demonstrated in scientific research. Optimized molar composition, microstructure, and average molar mass of PLGA-oTMC ensured an appropriate melt viscosity, facilitating 3D printing
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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