SVF
Level D· Preclinical EvidenceAnimal Study

Evaluation of the management of rotator cuff injuries utilising superparamagnetic iron oxide tracking stem cells.

Cheng Z., Liu D., Park JY., Meng X., Yang Y., Dang M.

Animal Study on Tendon Injury, Rotator Cuff, Scar, Chronic Inflammation, published in Tissue Cell (2025) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Animal Study
Journal
Tissue Cell (2025)
Country
Scotland
Reported sample size
—
PMID
40081255
DOI
10.1016/j.tice.2025.102836

Abstract (original English)

The ultrastructure of the tendon-bone interface (TBI) is inherently complex. After arthroscopic reconstruction, it is often replaced by disorganized scar tissue, which increases the risk of re-tearing.Stem cell therapies offer a promising approach to regenerate the original tissue structure and enhance the healing environment. The effectiveness of these therapies depends on understanding the localization, proliferation, and overall behavior of the implanted stem cells. This study aimed to track the distribution of stem cells in a rat model of rotator cuff injury using Magnetic Resonance Imaging (MRI) and superparamagnetic iron oxide nanoparticles (SPIO) and to evaluate the mechanisms and therapeutic effects of stem cell therapy. Adipose-derived mesenchymal stem cells (ADSCs) were isolated and expanded, then labeled with SPIO at an optimized concentration. The visibility of these labeled cells was assessed via MRI, along with evaluations of their viability, potential toxicity, and migration capacity in vitro.For the in vivo study, rats with rotator cuff tears were divided into two groups: a control group that received a PBS injection, and a treatment group that received SPIO-labeled ADSCs (designated as S-A). MRI scans were conducted at 1, 2, and 4 weeks post-surgery, followed by histological analysis after the rats were euthanized. At 8 weeks post-surgery, rats were sacrificed,

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence
AnimalsRotator Cuff InjuriesMesenchymal Stem CellsRatsMagnetic Resonance ImagingMagnetic Iron Oxide NanoparticlesMesenchymal Stem Cell TransplantationCell TrackingRats, Sprague-DawleyMale
Face & SkinShoulderTendon InjuryRotator CuffScarChronic Inflammation
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