Level C· Early human research exploring benefitsProspective StudyEurope PMCOpen access

The Evolution of Knifeless Microcolumn Fat Injection in 1362 Patients: Emphasizing Longevity of Results and Optimal Contour

Sullivan PK., Palmer SK., Gomez DA.

Prospective Study with a reported sample of 1362 on Scar, published in Plast Reconstr Surg Glob Open (2025) — summary generated from the PubMed abstract.

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Level C· Early human research exploring benefitsEvidence level of this study

Early human evidence such as case series or small samples is exploring possible benefits.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
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This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Prospective Study
Journal
Plast Reconstr Surg Glob Open (2025)
Reported sample size
1362
Source database
Europe PMC
PMID
40995578
PMCID
PMC12456580
DOI
10.1097/gox.0000000000007118

Abstract (original English)

Background The field of regenerative surgery has been revolutionized by minimally invasive fat injection methods. Over the past decades, techniques have evolved significantly. However, concerns regarding long-term volume retention and creating the desired result remain a challenge for many surgeons. Methods Our experience with 1362 patients has led to the development of a refined microfat injection technique that achieves durable facial contouring with a single treatment. Our method eliminates the need for overinjection, reducing the risks of contour irregularities and unpredictable fat resorption. The technique is knife-free, minimizing scarring and improving patient satisfaction. Results Meticulous preoperative planning is paramount. Targeted areas are drawn on the face and delineated in subunits. These recipient sites undergo preinjection with a vasoconstrictive agent, mirroring the planned fat volume. This allows intraoperative assessment and precise volume refinement. Fat is harvested, processed, and injected in microcolumns using blunt side-port cannulas ranging from 17 to 20 G cannulas, with each pass depositing 0.025 to 0.05 mL in a new vascularized plane. This systematic microcolumnar deposition of small threads of fat ensures uniform augmentation, optimal vascularization, and long-term volume preservation. Conclusions This technique is particularly advantageous to del

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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