Exercise during pregnancy modulates infant cellular and whole-body adiposity.
Claiborne A., Jevtovic F., Zheng D., Strom C., Wisseman B., McDonald S.
Prospective Study, published in Physiol Rep (2024) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Physiol Rep (2024)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 39617638
- DOI
- 10.14814/phy2.70145
Abstract (original English)
Non-pharmaceutical interventions are needed to target the growing intergenerational cycle of obesity. We aimed to determine whether in utero exposure to different exercise doses during pregnancy directly reduces infant cellular and whole-body adiposity. Pregnant women completed ~24 weeks of supervised exercise training; for standardization of exercise analysis (frequency, intensity, time, and volume-FIT-V), metrics were assessed from 16 to 36 weeks. Mesenchymal stem cells (MSC) collected from the umbilical cord at delivery underwent 21 days of adipogenic differentiation, then Oil Red O staining for lipid content. Infant body composition was measured at 1 month of age. ANCOVA and Pearson correlations determined the influence of prenatal exercise on infant adiposity. Exercise decreased infant MSC lipid content (p = 0.01) and body fat percentage (p = 0.009) irrespective of dose. Total exercise volume throughout pregnancy was negatively correlated with infant body fat % (R 2 = 0.31, p = 0.02) due to lower subscapular skinfolds (R 2 = 0.30, p = 0.02), while weekly exercise duration influenced adipogenic MSC lipid accumulation (R 2 = -0.23, p = 0.03) and BF% (R 2 = -0.15, p = 0.01). In utero exposure to exercise reduced cellular and whole-body infant adiposity in a dose-dependent manner.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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