Exercise rejuvenates bone marrow mesenchymal stem cells associated with the inhibition of inflammatory factors and senescence-related factors
Dong XJ., Zhao Q., Zhang WM., Liu JG., Zhang XD., Yi R.
Laboratory Study, published in Biochem Biophys Rep (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Biochem Biophys Rep (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 42004533
- PMCID
- PMC13090148
- DOI
- 10.1016/j.bbrep.2026.102561
Abstract (original English)
Objective To investigate the effects of exercise on bone marrow stem cells (BMSCs) and determine underlying molecular network mechanisms through bioinformatics analysis combined experimental validation. Methods Target genes related to exercise and BMSCs were retrieved from the Gene Cards database and deduplicated, then performed bioinformatics analysis including Venny analysis, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), protein-protein interaction (PPI) and cystoscope to find hub genes. In animal experiment, 9-month-old male C57BL/6J mice were subjected to 4 months of treadmill exercise training (12 m/min, 1 h/day, 5 days/week) and the BMSCs from femur were cultured in vitro, and cell viability, the expression of cell senescence-related factors (P16, P21) and inflammatory factors (IL-6, IL-1β) were detected, and the vital role of IL-6, IL-1β was determined in vitro study. Results 131 common targets were found via Venn diagram analysis. The STRING database and Cytoscape software identified several core molecules such as IL-1β, IL6, TNF, and stat3, etc. GO enrichment analysis revealed that these common targets were primarily involved in biological processes such as negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, leukocyte chemotaxis, and positive regulation of protein phosphorylation; cellular components such
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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