Exosome-Based Therapy: A Comparative Study of Adipose- and Umbilical Cord-Derived Mesenchymal Stem Cells-Derived Exosomes in Psoriatic Mouse Model.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Exosomes are nanosized extracellular vesicles that mediate intercellular communication by transferring bioactive molecules. Mesenchymal stem cells (MSCs) from different tissue sources secrete exosomes with potentially distinct therapeutic properties. In this study, we compared the anti-inflammatory efficacy of exosomes derived from human adipose-derived MSCs (hADMSCs-EXOs) and human umbilical cord-derived MSCs (hUCMSCs-EXOs), together with desoximetasone (DSM), in an imiquimod-induced psoriasis mouse model. Psoriasiform lesions were induced, and treatment outcomes were assessed through clinical, histological, and immunological assessments. Both hADMSCs-EXOs and hUCMSCs-EXOs significantly attenuated psoriasiform lesions, as clinically evidenced by reduced cumulative Psoriasis Severity Index (PSI) scores by day 6 of treatment. Notably, hUCMSCs-EXOs and DSM significantly reduced epidermal and dermal thickness to no significant difference compared to the control group. Immune cell infiltration, including CD3 + , CD4 + , CD8 + T cells, CD68 + macrophages, CD117 + mast cells, and neutrophils, was also markedly reduced in the hUCMSCs-EXOs and DSM groups. Importantly, unlike DSM, hUCMSCs-EXOs did not induce skin thinning or systemic adverse effects. Growth factor (GF) profiling revealed that hADMSCs-EXOs were enriched in FGFs, PDGFs, and VEGF, whereas hUCMSCs-EXOs contained higher leve

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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