Exosome-based therapy for epilepsy: a systematic review and meta-analysis of preclinical studies

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Objective This study aims to quantitatively assess the efficacy of exosome therapy for epilepsy through a systematic review and meta-analysis of preclinical animal experiments. We seek to clarify its overall effects on seizure reduction, cognitive function preservation, and neuroinflammation suppression. Methods A systematic search was conducted across four English-language and four Chinese databases to include epilepsy animal studies. Continuous outcomes were synthesized using standardized mean differences (SMD) and 95% confidence intervals (CI), with fixed or random effects models selected based on heterogeneity. Results A total of eight preclinical studies were included. The overall meta-analysis revealed that exosome treatment significantly reduced the duration of seizures (SMD = -2.30, 95% CI -4.24 to -0.36), decreased the frequency of spontaneous recurrent seizures (SMD = -1.38, 95% CI -2.17 to -0.58), and prolonged the seizure latency (SMD = 1.49, 95% CI 0.08-2.90). In terms of cognitive function, exosomes significantly shortened the escape latency in the Morris water maze (SMD = -1.38, 95% CI -2.17 to -0.58), increased the percentage of time spent in the target quadrant (SMD = 3.69, 95% CI 0.30-7.08), and enhanced the number of platform crossings (SMD = 1.41, 95% CI 0.60-2.21), with no significant changes in swimming speed. Neuropathological analysis indicated that exos

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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