[Experimental substantiation of medical device design for mechanical processing of adipose tissue].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

To substantiate the medical device design for mechanical processing of adipose tissue. Enzymatic method using collagenase and mechanical method for obtaining the stromal vascular fraction (SVF) are compared. The authors emphasized the disadvantages of enzymatic method, such as high cost and duration of process. The main criteria for developing the design were cell viability after processing of adipose tissue and available processing in a minimum number of passages manually without automated mechanical stands. The proposed design allows two unidirectional passages to obtain processed lipoaspirate for SVF harvesting. Experimental studies demonstrate that meshes with a minimum cell size of 100 μm allow high cell viability comparable to enzymatic method. Moreover, this design can be used to develop a disposable medical device. Our results will underlie development of a disposable medical device for mechanical processing of adipose tissue. Обосновать конструкцию медицинского изделия для механической обработки жировой ткани. Выполнено сравнение ферментативного метода с использованием коллагеназы и механического метода получения стромально-васкулярной фракции (СВФ), при этом акцентируется внимание на недостатках ферментативного метода, таких как высокая стоимость и длительность процесса. Основными критериями при разработке конструкции являлись выживаемость клеток после обработки жиров

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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