Exploration of biomaterial and stem cell-based strategies for promoting neuronal regeneration and creating engineered 3D in-vitro disease models
Khodve G., Banerjee S., Kumari M., Ravichandiran V., Banerjee S., Roy S.
Narrative Review, published in J Transl Med (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- J Transl Med (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41168786
- PMCID
- PMC12574274
- DOI
- 10.1186/s12967-025-07266-9
- Citations
- 5
Abstract (original English)
The adult brain can produce only a relatively small number of new neurons, and neurogenesis occurs only in specific brain areas. Post-neuronal injury self-repair is very slow and sometimes does not occur. Therefore, advancements in regenerative therapies play an essential role in recovery from damage. This review focuses on stem cell-based neuronal repair by using biomaterials. We discuss neural tissue damage and the associated mechanisms in neuronal repair, highlighting the role of B cells along with VGLUT1/VGLUT2 (vesicular glutamate transporter 1/2) terminals and glutamate AMPA receptors, IL-1R1 signalling, and ERK/Stat6/MERTK Signalling. Furthermore, it focuses on the types of biomaterials, their characteristics, and mechanisms to overcome neuronal damage repair challenges using modern biomaterial-dependent neuronal tissue engineering techniques. Axonal regeneration can be enhanced by mixing many components (biomaterials, cells, and chemicals) to recover from neural nerve illnesses. Polymers, such as collagen, gelatin, chitosan, alginate, hyaluronan, silk fibroin, poly(L-lactic acid), poly(glycolic acid), polycaprolactone, polyphosphoester, and polyurethane, have been used to aid nerve cell growth. These polymers can be either natural or synthetic. Biomaterials that conduct electricity, such as polypyrrole, polythiophene, and polyaniline, can help neurites grow and make cel
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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